This powerful peptide transforms tired eyes into a fresh, lifted, and well rested look. Discover why beauty insiders, actresses, and supermodels swear by it.
by Kristina Mikulić GazdovićNovember 28, 2025
One of the best places to look for beauty tricks that truly work is the backstage area of fashion shows. This autumn I noticed that, in addition to the expected hair and makeup teams, some shows like Altuzarra and Tove also had dedicated beauty teams taking care of skin preparation for the models. The focus was especially on the under-eye area and dark circles.
What caught my eye in particular was the blue Cryo De-Puffing Eye Mask by 111Skin. A few months later, while researching various topics across different beauty categories, I kept seeing this blue mask on models and actresses.
It is one of Anne Hathaway’s favorite masks, and Aleks Consani and Paloma Elsesser also reach for this powerful formula. Supermodel Candice Swanepoel used this very mask to prep her skin before stepping onto the Victoria’s Secret runway. Naturally, that made me want to find out what makes it so effective. The answer, of course, was peptides.
Courtesy of 111Skin
There are truly many types of peptides. Some stimulate collagen or melanin synthesis, while others support exfoliation. The search therefore had to go deeper. The peptide responsible for the impressive results of this beloved mask on dark circles is known as Acetyl Tetrapeptide 5. You will also find it under the trademarked name Eyeseryl. But how does this peptide work and why is it so loved by makeup artists, models, and actresses?
Acetyl Tetrapeptide 5 delivers two key actions that are often needed in the under eye area:
This powerful peptide not only significantly reduces puffiness but also offers an anti aging effect because it protects collagen fibers. This is especially helpful if we have overdone it with sugar. Sugar binds easily to collagen, causing damage and wrinkles. Since modern diets contain an excessive amount of sugar (even in foods where we do not expect it, such as plain yogurt), it is beneficial to include formulas in your routine that counteract glycation.
Like most peptides, you can use it very easily and combine it with other steps in your routine. You can reach for eye serums, such as Liposmose by Biologique Recherche, which is Bella Hadid’s favorite eye serum that she showed in Vogue Beauty Secrets, and you can also use it daily in an eye cream.
For a quick fix, under eye masks like the popular 111Skin Cryo De Puffing Eye Mask work very well, and the most affordable option is The Ordinary Multi Peptide Eye Serum. For sensitive eyes, Bioderma Sensibio Eye Gel is an excellent option that addresses several concerns at once.
No matter which texture you choose, this powerful peptide that reduces puffiness and swelling will not disappoint you.
