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Photo: Courreges Spring 2026., Acielle/ Style du Monde
Photo: Courreges Spring 2026., Acielle/ Style du Monde
Skin

The science behind reviving skin dulled by modern life

Meet neuroproline, the ingredient that helps your skin cope with a problem we can no longer avoid.

by Kristina Mikulić Gazdović

November 12, 2025

There is much talk and even more writing about the impact of chronic physical or psychological stress on the human body. Stress is natural and, in certain situations, even desirable as a response of the human body to external factors. However, what becomes problematic is chronic stress. A lack of relaxation periods and decreased cortisol levels is a state described as chronic stress.

The consequences can vary, but the hair and skin are often the first to suffer. The effects of chronic stress on hair and skin are also the easiest to notice. Premature hair loss, thinning, or excessive scalp oiliness can all be warning signs. And while there are many options available today to address hair-related issues, things become more complex when it comes to the skin. Yet one ingredient deserves your attention, as it helps prevent many skin problems caused by chronic stress. Meet neuroproline.

What is neuroproline?

Neuroproline is the name of a natural complex primarily derived from the seeds of the Tephrosia purpurea plant, also known as wild indigo. The extract is often used in Ayurvedic skincare traditions. On ingredient lists, you will find this complex as a combination of propanediol and Tephrosia Purpurea Seed Extract. It is water-soluble, which is why it is mainly found in facial serums and creams. Even a small concentration of 0.5% delivers results, while skincare products can contain doses of up to 2%.

žena nanosi gel serum na lice

Photo: Junessa Rendon

How does neuroproline work?

Neuroproline acts on cortisol produced by the skin. It effectively prevents the production of cortisol in the skin within two hours of application. But aside from reducing this hormone, neuroproline has another important effect. It stimulates skin cells to produce beta-endorphins, the “feel-good” hormones that help regulate stress. In other words, you can think of neuroproline as neutralizing the effects of cortisol on the skin and helping it “relax.”

How do chronic stress and elevated cortisol affect the skin?

You may have noticed from your own experience that after a long period of stress, your skin tends to look older, drier, less radiant, and less elastic, while inflammation and redness are also common. All these skin conditions can result from chronic stress, as well as from lack of sleep, unprotected sun exposure, polluted air, or invasive skin treatments.

  • It reduces collagen production, leading to premature aging and loss of elasticity.
  • It decreases the skin’s natural ability to regenerate, which makes the complexion appear dull and tired.
  • It increases inflammation, causing redness and breakouts.
  • It disrupts the natural production of protective lipids, making the skin appear dry.
  • It can trigger the formation of dark spots and uneven skin tone.
  • It negatively affects the skin’s microbiome, weakening its barrier and making inflammation more frequent

When is the best time to use products with neuroproline?

It is beneficial to include products with neuroproline in your routine, either as a cream or serum, both in your morning and evening skincare if you:

  • live in a city with high air pollution
  • are exposed to a stressful lifestyle
  • have recently undergone an invasive cosmetic procedure
  • have extremely sensitive skin prone to redness and irritation

How to introduce neuroproline into your routine

Neuroproline is suitable for most skin types and concerns. Since it is only water-soluble, it should be applied to clean skin. For that reason, a serum containing neuroproline will usually be more effective than a cream. Before applying your cream or serum with neuroproline, avoid using oil-based or milky serums and facial mists. Such products often contain oils that can prevent proper absorption of this excellent Ayurvedic ingredient, reducing its effectiveness. Neuroproline starts working within two hours of application, while consistent, long-term use helps prevent the unwanted effects of chronically elevated cortisol in the skin.

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